منابع مشابه
Chemical sympathectomy alters the development of hypertension in miniature swine.
To determine if the neurotoxin 6-hydroxydopamine could be used to chemically sympathectomize neonatal miniature swine, eight newborn swine were treated with 6-hydroxydopamine beginning on the first day after birth and continuing at regular intervals for the next 6 months. Six littermates served as controls and received vehicle injections. A significant reduction in the pressor response to intra...
متن کاملChemical sympathectomy of the cat with 6-hydroxydopamine.
HAEUSLER, G., W. HAEFELY AND H. THOENEN: Chemical sympathectomy of the cat with 6-hydroxydopamine. J. Pharmacol. Exp. Then. 170: 50-61, 1969. Cats were given 6-hydroxydopamine (6-Oll-DA; 2,4,5-trihydnoxyphenethylamine) i.v. according to a schedule which had previously been found to produce a selective and almost complete destruction of peripheral adnenergic nerve terminals. After varying interv...
متن کاملChemical lumbar sympathectomy in patients with severe lower limb ischaemia.
Over a 13 year period, 544 chemical lumbar sympathetic blocks with phenol in 489 patients were performed by the author with the aid of X-ray image intensification. There was objective and subjective improvement in the signs and symptoms of limb ischaemia in 72%, judged by relief of rest pain, improvement in skin blood flow or healing of ischaemic ulcers. Of patients treated in the years 1990-19...
متن کاملChemical allergy: translating biology into hazard characterization.
The induction by chemicals of allergic sensitization and allergic disease is an important and challenging branch of toxicology. Skin sensitization resulting in allergic contact dermatitis represents the most common manifestation of immunotoxicity in humans, and many hundreds of chemicals have been implicated as skin sensitizers. There are far fewer chemicals that have been shown to cause sensit...
متن کاملComputational Approaches to Chemical Hazard Assessment
Computational prediction of toxicity has reached new heights as a result of decades of growth in the magnitude and diversity of biological data. Public packages for statistics and machine learning make model creation faster. New theory in machine learning and cheminformatics enables integration of chemical structure, toxicogenomics, simulated and physical data in the prediction of chemical heal...
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ژورنال
عنوان ژورنال: BMJ
سال: 1978
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6132.279-a